5-Fluorouracil Cream (Efudex®, Carac®).
This chemotherapy cream is most commonly used for the treatment of actinic keratosis, pre-cancerous growths. It is also FDA approved for the treatment of non-facial superficial basal cell carcinomas. Treatment results in mild to severe skin irritation. It is 88% effective for the treatment of superficial basal cell carcinomas, which is lower than other treatment modalities. Treatment usually does not result in scarring, although skin discoloration (slight lightening or darkening) may occur in some and can be permanent.